The platform · Closed-loop vector discovery
THE AUTONOMOUS LAB FOR
EXOSOME DISCOVERY
Exosomes are nature's vector. We're building the design engine for each layer, one at a time.
THE STACK · FOUR TUNABLE LAYERS
Four Layers. One Vector
L1
● Engine LIVE
Surface
Ligands displayed on Lamp2b. Fold and binding scored in silico.
L2
Next
Cargo
RNA and protein payloads. Loading efficiency vs integrity.
L3
Next
Manufacturing
Cell line and process tuned for yield, potency, batch consistency.
L4
Next
QC
Size, count, markers, purity, potency — scored every batch.
Layer 1 · Surface · The live design engine
Pick a tissue. Design the ligand, in silico.
Every tissue has an address. The engine proposes ligands for that target on Lamp2b. Three in-silico gates: display, fold, bind.
Tropism library · pick the tissue address
6 tissues · one engine
SelectedNeural·TargetTfR1·Intranasal · CNS-adjacent delivery
Target TfR1 (Neural)Scaffold Lamp2bEngine BindCraftEXO-1 · Surface ligand
Three in-silico gates. The bench decides everything past Bind.
G1
DISPLAY
Lamp2b-fusion compatibility — ligand tolerates surface display geometry
G2
FOLD
AlphaFold2 confidence — ligand folds as designed
G3
BIND
Interface confidence — predicted binding to target receptor (e.g. TfR1)
↦
→
Wet lab
DSN-01
·
DSN-02
·
DSN-03
·
DSN-04
·
DSN-05
·
DSN-06
·
PassRunningQueuedDropped→ Wet lab
Illustrative · live numbers will replace this once the engine's first run lands.
The wet-lab loop
The dry lab proposes. The wet lab decides.
Uptake and tropism are bench calls. Survivors enter a build-test cycle; results re-rank the next round.
Automated lab · live loop
Synthesize
Liquid handling · peptide CRO build
Display
Lamp2b surface anchoring · QC scan
Bioreactor
Producer
Uptake yield
Δ vs control
Receptor+ yield
Test uptake
Bench decides · re-ranks the next round
Automated lab · live loop
Synthesize
Liquid handling · peptide CRO build
Bioreactor
Producer
Live
Display
Lamp2b surface anchoring · QC scan
Uptake
Δ vs control
Receptor+ / Receptor−
Test uptake
Bench decides · re-ranks the next round
Buffer
4.0°C
Flow
1.2 ml/s
Results re-rank the next design round
Product pipeline
Product
Discovery
Pre-clinical
Planned
EXO-1Gen-1
Intranasal · CNS · siRNA · TfR1-targeted ligand
EXO-2Gen-2
Multiplexed ligands · multi-tissue
EXO-3Gen-3
Next-gen programmable vector
CompletedCurrentPlanned